Top 10 Weight Loss Medications of 2025

Compare the most effective FDA-approved medications for sustainable weight loss

#1 Most Popular

Mounjaro

Tirzepatide

4.9 (124 reviews)
First FDA-approved GLP-1 and GIP dual agonist for type 2 diabetes
Proven to help you lose up to 22.5% of body weight in clinical trials
Recent studies show best weight loss results among all medications
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Saxenda

Liraglutide

4.7 (89 reviews)
FDA approved for chronic weight management
5% or greater weight loss results
Proven appetite suppression
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Wegovy

Semaglutide

4.8 (112 reviews)
Weekly self-injection (GLP-1 receptor)
Up to 15% body weight reduction
Similar to Ozempic but specifically approved for weight loss
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Qsymia

Phentermine-Topiramate

4.5 (95 reviews)
Combination of appetite suppressant and seizure medication
Reduced food cravings and hunger
FDA approved for long-term use
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Orlistat

Xenical/Alli

4.3 (78 reviews)
Prevents fat absorption in intestines
Available as prescription (Xenical) or over-the-counter (Alli)
Long safety record
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Family's Choice - March 2025

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Mounjaro

Tirzepatide

4.9
124 reviews
  • First FDA-approved GLP-1 and GIP dual agonist for type 2 diabetes
  • Proven to help you lose up to 22.5% of body weight in clinical trials
  • Recent studies show best weight loss results among all medications
Get Offer

Saxenda

Liraglutide

4.7
89 reviews
  • FDA approved for chronic weight management
  • 5% or greater weight loss results
  • Proven appetite suppression
Get Offer

Wegovy

Semaglutide

4.8
112 reviews
  • Weekly self-injection (GLP-1 receptor)
  • Up to 15% body weight reduction
  • Similar to Ozempic but specifically approved for weight loss
Get Offer

Qsymia

Phentermine-Topiramate

4.5
95 reviews
  • Combination of appetite suppressant and seizure medication
  • Reduced food cravings and hunger
  • FDA approved for long-term use
Get Offer

Orlistat

Xenical/Alli

4.3
78 reviews
  • Prevents fat absorption in intestines
  • Available as prescription (Xenical) or over-the-counter (Alli)
  • Long safety record
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Zepbound

Tirzepatide

4.6
65 reviews
  • New FDA-approved version of Mounjaro
  • Once-weekly injection
  • Specifically approved for weight loss
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Rybelsus

Oral Semaglutide

4.4
72 reviews
  • Works similarly to Wegovy/Ozempic
  • Available as a daily pill instead of injection
  • First oral GLP-1 receptor
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Plenity

Gelesis100

4.2
68 reviews
  • Not technically a medication
  • FDA-cleared as a device in pill form
  • Expands in stomach to help you feel full
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Naltrexone-Bupropion

Contrave

4
83 reviews
  • Combination anti-addiction and antidepressant medication
  • Works on brain pathways associated with hunger and cravings
  • Moderate weight loss results
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Phentermine

Adipex-P, Lomaira

3.7
96 reviews
  • Short-term appetite suppressant
  • One of the oldest weight loss medications still in use
  • Approved only for short-term use
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